T cells and related cytokines

J Dudler, AKL So - Current opinion in rheumatology, 1998 - journals.lww.com
J Dudler, AKL So
Current opinion in rheumatology, 1998journals.lww.com
T cells play a critical role in rheumatoid arthritis. They are probably continuously involved in
pathogenesis, from the initiation to the chronic stage. As recent studies have demonstrated,
the part they play in rheumatoid arthritis is closely linked to the roles of macrophages and
mesenchymal cells, because they all interact through autocrine, paracrine, and cell-contact
pathways. This paper reviews recent work and research regarding the specific role of T cells
in the pathogenesis of rheumatoid arthritis.
Abstract
T cells play a critical role in rheumatoid arthritis. They are probably continuously involved in pathogenesis, from the initiation to the chronic stage. As recent studies have demonstrated, the part they play in rheumatoid arthritis is closely linked to the roles of macrophages and mesenchymal cells, because they all interact through autocrine, paracrine, and cell-contact pathways. This paper reviews recent work and research regarding the specific role of T cells in the pathogenesis of rheumatoid arthritis.
Lippincott Williams & Wilkins