Interleukin 15: a proinflammatory role in rheumatoid arthritis synovitis
IB McInnes, FY Liew - Immunology today, 1998 - cell.com
IB McInnes, FY Liew
Immunology today, 1998•cell.comIn rheumatoid arthritis (RA), locally produced interleukin 15 (IL-15) can recruit and activate
synovial T cells, which then amplify and perpetuate inflammation through induction of
monocyte-derived tumour necrosis factor α (TNF-α) via a cell-contact-dependent
mechanism. Thus, IL-15 could play a pivotal role in disease pathogenesis, acting upstream
of TNF-α in orchestrating the induction of a cascade of inflammatory cytokines.
synovial T cells, which then amplify and perpetuate inflammation through induction of
monocyte-derived tumour necrosis factor α (TNF-α) via a cell-contact-dependent
mechanism. Thus, IL-15 could play a pivotal role in disease pathogenesis, acting upstream
of TNF-α in orchestrating the induction of a cascade of inflammatory cytokines.
Abstract
In rheumatoid arthritis (RA), locally produced interleukin 15 (IL-15) can recruit and activate synovial T cells, which then amplify and perpetuate inflammation through induction of monocyte-derived tumour necrosis factor α (TNF-α) via a cell-contact-dependent mechanism. Thus, IL-15 could play a pivotal role in disease pathogenesis, acting upstream of TNF-α in orchestrating the induction of a cascade of inflammatory cytokines.
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