4ps/insulin receptor substrate (irs)-2 is the alternative substrate of the insulin receptor in irs-1-deficient mice (∗)
Insulin receptor substrate-1 (IRS-1) is the major cytoplasmic substrate of the insulin and
insulin-like growth factor (IGF)-1 receptors. Transgenic mice lacking IRS-1 are resistant to
insulin and IGF-1, but exhibit significant residual insulin action which corresponds to the
presence of an alternative high molecular weight substrate in liver and muscle. Recently,
Sun et al.(Sun, X.-J, Wang, L.-M., Zhang, Y., Yenush, LP, Myers, MG, Jr., Glasheen, E., Lane,
WS, Pierce, JH, and White, MF (1995) Nature 377, 173-177) purified and cloned 4PS, the …
insulin-like growth factor (IGF)-1 receptors. Transgenic mice lacking IRS-1 are resistant to
insulin and IGF-1, but exhibit significant residual insulin action which corresponds to the
presence of an alternative high molecular weight substrate in liver and muscle. Recently,
Sun et al.(Sun, X.-J, Wang, L.-M., Zhang, Y., Yenush, LP, Myers, MG, Jr., Glasheen, E., Lane,
WS, Pierce, JH, and White, MF (1995) Nature 377, 173-177) purified and cloned 4PS, the …
