A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization
VP Sukhatme, X Cao, LC Chang, CH Tsai-Morris… - Cell, 1988 - cell.com
VP Sukhatme, X Cao, LC Chang, CH Tsai-Morris, D Stamenkovich, PCP Ferreira, DR Cohen…
Cell, 1988•cell.comEgr-7 is an early growth response gene that displays fos-like induction kinetics in fibroblasts,
epithelial cells, and lymphocytes following mitogenic stimulation. Sequence analysis of
murine Egr. 7 cDNA predicts a protein with three DNA binding zinc fingers. The human
EGR7 gene maps to chromosome 5 (bands 5q23-31). Egr-1 mRNA increases dramatically
during cardiac and neural cell differentiation, and following membrane depolarization both
in vitro and in vivo. Thus, Egr-7 and c-fos are often coregulated with strikingly similar …
epithelial cells, and lymphocytes following mitogenic stimulation. Sequence analysis of
murine Egr. 7 cDNA predicts a protein with three DNA binding zinc fingers. The human
EGR7 gene maps to chromosome 5 (bands 5q23-31). Egr-1 mRNA increases dramatically
during cardiac and neural cell differentiation, and following membrane depolarization both
in vitro and in vivo. Thus, Egr-7 and c-fos are often coregulated with strikingly similar …
Summary
Egr-7 is an early growth response gene that displays fos-like induction kinetics in fibroblasts, epithelial cells, and lymphocytes following mitogenic stimulation. Sequence analysis of murine Egr. 7 cDNA predicts a protein with three DNA binding zinc fingers. The human EGR7 gene maps to chromosome 5 (bands 5q23-31). Egr-1 mRNA increases dramatically during cardiac and neural cell differentiation, and following membrane depolarization both in vitro and in vivo. Thus, Egr-7 and c-fos are often coregulated with strikingly similar kinetics. These results, in conjunction with the Egr-1 primary structure, suggest that Egr-1 may function as a transcriptional regulator in diverse biological processes.
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