Autoantibody-mediated capture and presentation of autoantigen to T cells via the Fcε receptor by a recombinant human autoantibody Fab converted to IgE
J Guo, S Quaratino, JC Jaume, G Costante… - Journal of …, 1996 - Elsevier
Fcε receptor (CD23)-mediated capture of IgE-antigen complexes by B cells provides a
powerful antigen presenting system. Our goal was to develop a system using high affinity,
human, organ-specific monoclonal autoantibodies for antigen capture by B cells. For this
purpose, we converted a recombinant human autoantibody to TPO from a Fab (SP1. 4) to an
IgE molecule. Sera from all patients with autoimmune thyroid disease contain
autoantibodies with the same epitope as SP1. 4. The SP1. 4 and L chain V region genes …
powerful antigen presenting system. Our goal was to develop a system using high affinity,
human, organ-specific monoclonal autoantibodies for antigen capture by B cells. For this
purpose, we converted a recombinant human autoantibody to TPO from a Fab (SP1. 4) to an
IgE molecule. Sera from all patients with autoimmune thyroid disease contain
autoantibodies with the same epitope as SP1. 4. The SP1. 4 and L chain V region genes …
