Free amino acid levels in serum and small intestine during the post-natal development of normal and sparse-fur mutant mice
C Malo - Comparative Biochemistry and Physiology Part A …, 1994 - Elsevier
Ornithine transcarbamylase (OTC) is a mitochondrial enzyme which catalyzes the
conversion of ornithine into citrulline. In sparse-fur (spf) mutant mice, in which both hepatic
and small intestinal OTC are deficient, only small amounts of citrulline are released into the
blood. To evaluate the fate of ornithine as well as the levels of substrates and products of
these metabolic pathways in normal and OTC-deficient mice, we measured the
concentration of free amino acids in small intestinal mucosa and serum during post-natal …
conversion of ornithine into citrulline. In sparse-fur (spf) mutant mice, in which both hepatic
and small intestinal OTC are deficient, only small amounts of citrulline are released into the
blood. To evaluate the fate of ornithine as well as the levels of substrates and products of
these metabolic pathways in normal and OTC-deficient mice, we measured the
concentration of free amino acids in small intestinal mucosa and serum during post-natal …
