Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive …

BM Brenner, TW Meyer… - New England Journal of …, 1982 - Mass Medical Soc
BM Brenner, TW Meyer, TH Hostetter
New England Journal of Medicine, 1982Mass Medical Soc
IT is now more than 30 years since Addis suggested that protein intake be restricted in
patients with chronic renal insufficiency. 1 His aim was not to reduce uremic symptoms but
rather to prevent an increase in the" workload" of surviving nephrons of diseased kidneys in
order to minimize further loss of renal function. With the development and increasingly
widespread availability of dialysis and transplantation in the past three decades, relatively
little attention has been paid to the influence of diet on the progression of renal disease …
IT is now more than 30 years since Addis suggested that protein intake be restricted in patients with chronic renal insufficiency.1 His aim was not to reduce uremic symptoms but rather to prevent an increase in the "workload" of surviving nephrons of diseased kidneys in order to minimize further loss of renal function. With the development and increasingly widespread availability of dialysis and transplantation in the past three decades, relatively little attention has been paid to the influence of diet on the progression of renal disease, despite general awareness that renal disease typically follows an inexorably progressive course. In this . . .
The New England Journal Of Medicine