Progression to end-stage renal failure is the final common pathway of many forms of
glomerular disease, independent of the type of initial insult. Progressive glomerulopathies
have in common persistently high levels of urinary protein excretion and tubulointerstitial
lesions at biopsy. Among the cellular mechanisms that may determine progression
regardless of etiology, the traffic of excess proteins filtered from glomerulus in renal tubule
may have functional importance by initiating interstitial inflammation in the early phase of …