[HTML][HTML] Angiotensin II increases macrophage-mediated modification of low density lipoprotein via a lipoxygenase-dependent pathway
KJ Scheidegger, S Butler, JL Witztum - Journal of Biological Chemistry, 1997 - ASBMB
The molecular and cellular mechanisms by which hypertension enhances atherosclerosis
are poorly understood. Angiotensin II (Ang II) has been implicated in the regulation of
cellular lipoxygenases (LO), which are thought to play a role in atherogenesis by inducing
oxidative modification of low density lipoprotein (LDL). We sought to test the hypothesis that
Ang II would stimulate murine macrophage LO activity (which has both 12-and 15-LO
activity). Competitive binding studies revealed the presence of Ang II AT 1 receptors on …
are poorly understood. Angiotensin II (Ang II) has been implicated in the regulation of
cellular lipoxygenases (LO), which are thought to play a role in atherogenesis by inducing
oxidative modification of low density lipoprotein (LDL). We sought to test the hypothesis that
Ang II would stimulate murine macrophage LO activity (which has both 12-and 15-LO
activity). Competitive binding studies revealed the presence of Ang II AT 1 receptors on …