Pharmacological characterization of receptor-activity-modifying proteins (RAMPs) and the human calcitonin receptor
SL Armour, S Foord, T Kenakin, WJ Chen - Journal of pharmacological and …, 1999 - Elsevier
Receptor-activity-modifying proteins (RAMPs) are a family of single transmembrane domain
proteins shown to be important for the transport and ligand specificity of the calcitonin gene-
related peptide (CGRP) receptor. In this report, we describe the analysis of pharmacological
properties of the human calcitonin receptor (hCTR) coexpressed with different RAMPs with
the use of the Xenopus laevis melanophore expression system. We show that coexpression
of RAMP3 with human calcitonin receptor changed the relative potency of hCTR to human …
proteins shown to be important for the transport and ligand specificity of the calcitonin gene-
related peptide (CGRP) receptor. In this report, we describe the analysis of pharmacological
properties of the human calcitonin receptor (hCTR) coexpressed with different RAMPs with
the use of the Xenopus laevis melanophore expression system. We show that coexpression
of RAMP3 with human calcitonin receptor changed the relative potency of hCTR to human …
