Importance of glucose-6-phosphate dehydrogenase activity for cell growth
WN Tian, LD Braunstein, J Pang, KM Stuhlmeier… - Journal of Biological …, 1998 - ASBMB
The intracellular redox potential, which is determined by the level of oxidants and
reductants, has been shown to play an important role in the regulation of cell growth. The
principal intracellular reductant is NADPH, which is mainly produced by the pentose
phosphate pathway through the actions of glucose-6-phosphate dehydrogenase (G6PD),
the rate-limiting enzyme of the pentose phosphate pathway, and by 6-phosphogluconate
dehydrogenase. Previous research has suggested that an increase in G6PD activity is …
reductants, has been shown to play an important role in the regulation of cell growth. The
principal intracellular reductant is NADPH, which is mainly produced by the pentose
phosphate pathway through the actions of glucose-6-phosphate dehydrogenase (G6PD),
the rate-limiting enzyme of the pentose phosphate pathway, and by 6-phosphogluconate
dehydrogenase. Previous research has suggested that an increase in G6PD activity is …
