Professor of Medicine, University of Virginia Health Sciences Center, Charlottesville, Virginia): The present case was selected to illus-trate some of the typical features seen with Goodpasture's syndrome (GPS), as well as some of the atypical features that are of major clinical importance to the practicing nephrologist. This patient also illustrates some new ideas in diagnosis, prognosis, and therapy. The term" GPS" is an eponym derived from a report in 1919 by Ernest Goodpasture, who described the clinical syndrome of pulmonary hemorrhage associated with influenza infection and the histologic finding of acute creseentic glomerulonephritis (GN)[1, 21. We do not, as a matter of fact, know that the patients described by Goodpasture had anti-GBM disease. Over the years, the terminology has been used in different ways by different individuals, some including all causes of pulmonary hemorrhage with renal dysfunction as GPS [3]. Others limited the term GPS to patients with pulmonary hemorrhage associated with anti-GBM antibodies, as opposed to GN with anti-GBM antibodies but without pulmonary hemorrhage [4]. Yet others espouse the concept of anti-type-TV collagen disease rather than GPS [5]. Although most of the antibody activity is directed to the