Human calcitonin treatment of Paget's disease of bone
FR SINGER - Clinical Orthopaedics and Related Research®, 1977 - journals.lww.com
Human calcitonin is a 32 ami. no acid polypeptide hormone whose structure was
determined in 1968.18 The peptide was extracted from several medullary thyroid
carcinomas in sufficient quantities to allow sequencing. It was found to be present in 2 forms,
calcitonin M, the monomer and calcitonin D, the dimer linked through the sulphides at
positions 1 and 7. It has been assumed that tumor calcitonin is identical to calcitonin in the
normal human thyroid gland because of immunochemical similarity:% As yet, there has …
determined in 1968.18 The peptide was extracted from several medullary thyroid
carcinomas in sufficient quantities to allow sequencing. It was found to be present in 2 forms,
calcitonin M, the monomer and calcitonin D, the dimer linked through the sulphides at
positions 1 and 7. It has been assumed that tumor calcitonin is identical to calcitonin in the
normal human thyroid gland because of immunochemical similarity:% As yet, there has …
