Evaluation of the in Vivo and in Vitro Calcium Regulating Actions of Noncalcitonin Peptides Produced via Calcitonin Gene Expression
BA ROOS, JANA FISCHER, W PIGNAT… - …, 1986 - academic.oup.com
BA ROOS, JANA FISCHER, W PIGNAT, CB ALANDER, LG RAISZ
Endocrinology, 1986•academic.oup.comRecent studies of rat and human calcitonin (CT) gene expression have uncovered a
diversity of secretory peptides. Here we report the results of testing two such non-CT
secretory peptides for CT-like action in live rats and in cultured fetal rat long bone. One
peptide, the carboxyl-terminal CT-adjacent peptide that is cosynthesized with CT, has no
hypocalcemic effect and no inhibitory action on bone resorption in vitro. The other peptide,
CT gene-related peptide, lowers blood calcium and inhibits bone resorption. In vitro …
diversity of secretory peptides. Here we report the results of testing two such non-CT
secretory peptides for CT-like action in live rats and in cultured fetal rat long bone. One
peptide, the carboxyl-terminal CT-adjacent peptide that is cosynthesized with CT, has no
hypocalcemic effect and no inhibitory action on bone resorption in vitro. The other peptide,
CT gene-related peptide, lowers blood calcium and inhibits bone resorption. In vitro …
Abstract
Recent studies of rat and human calcitonin (CT) gene expression have uncovered a diversity of secretory peptides. Here we report the results of testing two such non-CT secretory peptides for CT-like action in live rats and in cultured fetal rat long bone. One peptide, the carboxyl-terminal CT-adjacent peptide that is cosynthesized with CT, has no hypocalcemic effect and no inhibitory action on bone resorption in vitro. The other peptide, CT gene-related peptide, lowers blood calcium and inhibits bone resorption. In vitro experiments are consistent with the idea that CT gene-related peptide is acting at CT receptors in bone. (Endocrinology118: 46–51, 1986)
Oxford University Press