[CITATION][C] Cytosine methylation targetted to pre-determined sequences
he incidence or severity of a number of human diseases is proportional to the activity
ofindividual viral transcription units or mutant endogenous genes. Tar-getted methylation of
regulatory sites is proposed as a new method for selective gene inactivation that stimulates
an existing biological response. Mammalian pro-moters are usually inactive when meth-(l
CpG-specific DNA methyltransferase
ofindividual viral transcription units or mutant endogenous genes. Tar-getted methylation of
regulatory sites is proposed as a new method for selective gene inactivation that stimulates
an existing biological response. Mammalian pro-moters are usually inactive when meth-(l
CpG-specific DNA methyltransferase
he incidence or severity of a number of human diseases is proportional to the activity ofindividual viral transcription units or mutant endogenous genes. Tar-getted methylation of regulatory sites is proposed as a new method for selective gene inactivation that stimulates an existing biological response. Mammalian pro-moters are usually inactive when meth-(l CpG-specific DNA methyltransferase
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