[PDF][PDF] The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21
A Cariappa, M Tang, C Parng, E Nebelitskiy, M Carroll… - Immunity, 2001 - cell.com
Immunity, 2001•cell.com
Most splenic B cells in mice that lack Aiolos are mature IgD hi IgM lo follicular lymphocytes,
suggesting that maturation signals delivered via the BCR are enhanced in the absence of
Aiolos. The enhanced maturation of follicular B cells is accompanied by the absence of MZ B
lymphocytes and the downregulation of CD21 expression in follicular B cells, all of which
depend on the generation of signals via Btk, which is in epistasis to Aiolos. The inverse
relationship between the strength of BCR signaling and MZ B cell development is supported …
suggesting that maturation signals delivered via the BCR are enhanced in the absence of
Aiolos. The enhanced maturation of follicular B cells is accompanied by the absence of MZ B
lymphocytes and the downregulation of CD21 expression in follicular B cells, all of which
depend on the generation of signals via Btk, which is in epistasis to Aiolos. The inverse
relationship between the strength of BCR signaling and MZ B cell development is supported …
Abstract
Most splenic B cells in mice that lack Aiolos are mature IgDhiIgMlo follicular lymphocytes, suggesting that maturation signals delivered via the BCR are enhanced in the absence of Aiolos. The enhanced maturation of follicular B cells is accompanied by the absence of MZ B lymphocytes and the downregulation of CD21 expression in follicular B cells, all of which depend on the generation of signals via Btk, which is in epistasis to Aiolos. The inverse relationship between the strength of BCR signaling and MZ B cell development is supported by an examination of MZ B cells in CD21 null mice. These data support the view that antigens (in contrast to "tonic" signals) drive the development of naive B cells.
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