[HTML][HTML] Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin α5
R Fagerlund, K Melén, L Kinnunen… - Journal of Biological …, 2002 - ASBMB
Interferon stimulation results in tyrosine phosphorylation, dimerization, and nuclear import of
STATs (signal transducers and activators of transcription). Proteins to be targeted into the
nucleus usually contain nuclear localization signals (NLSs), which interact with importin α.
Importin α binds to importin β, which docks the protein complex to nuclear pores, and the
complex translocates into the nucleus. Here we show that baculovirus-produced and-
activated STAT1 homodimers and STAT1-STAT2 heterodimers directly interacted with …
STATs (signal transducers and activators of transcription). Proteins to be targeted into the
nucleus usually contain nuclear localization signals (NLSs), which interact with importin α.
Importin α binds to importin β, which docks the protein complex to nuclear pores, and the
complex translocates into the nucleus. Here we show that baculovirus-produced and-
activated STAT1 homodimers and STAT1-STAT2 heterodimers directly interacted with …
