Some of the maternal symptoms of preeclampsia can be produced by uterine ischemia,
although no quadriped spontaneously exhibits this disease. It may be that the combination
of upright posture and uteroplacental ischemia are necessary for manifestation of the full
syndrome. Chronic nitric oxide synthase inhibition in rats produces a pattern of change that
resembles the symptoms of preeclampsia, and the preeclamptic-like response of rats with
adriamycin nephropathy and hyperinsulinemia is associated with endothelial dysfunction …