[HTML][HTML] Factor H binding to bone sialoprotein and osteopontin enables tumor cell evasion of complement-mediated attack
Metastatic cancer cells, like trophoblasts of the developing placenta, are invasive and must
escape immune surveillance to survive. Complement has long been thought to play a
significant role in the tumor surveillance mechanism. Bone sialoprotein (BSP) and
osteopontin (OPN, ETA-1) are expressed by trophoblasts and are strongly up-regulated by
many tumors. Indeed, BSP has been shown to be a positive indicator of the invasive
potential of some tumors. In this report, we show that BSP and OPN form rapid and tight …
escape immune surveillance to survive. Complement has long been thought to play a
significant role in the tumor surveillance mechanism. Bone sialoprotein (BSP) and
osteopontin (OPN, ETA-1) are expressed by trophoblasts and are strongly up-regulated by
many tumors. Indeed, BSP has been shown to be a positive indicator of the invasive
potential of some tumors. In this report, we show that BSP and OPN form rapid and tight …