[HTML][HTML] Peroxisome proliferator-activated receptor γ ligands inhibit retinoblastoma phosphorylation and G1→ S transition in vascular smooth muscle cells
S Wakino, U Kintscher, S Kim, F Yin, WA Hsueh… - Journal of Biological …, 2000 - ASBMB
Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the nuclear receptor
superfamily that is activated by binding certain fatty acids, eicosanoids, and insulin-
sensitizing thiazolidinediones (TZD). The TZD troglitazone (TRO) inhibits vascular smooth
muscle cell proliferation and migration both in vitro and in vivo. The precise mechanism of its
antiproliferative activity, however, has not been elucidated. We report here that PPARγ
ligands inhibit rat aortic vascular smooth muscle cell proliferation by blocking the events …
superfamily that is activated by binding certain fatty acids, eicosanoids, and insulin-
sensitizing thiazolidinediones (TZD). The TZD troglitazone (TRO) inhibits vascular smooth
muscle cell proliferation and migration both in vitro and in vivo. The precise mechanism of its
antiproliferative activity, however, has not been elucidated. We report here that PPARγ
ligands inhibit rat aortic vascular smooth muscle cell proliferation by blocking the events …
