A humanized anti–4-1BB monoclonal antibody suppresses antigen-induced humoral immune response in nonhuman primates
HJ Hong, JW Lee, SS Park, YJ Kang… - Journal of …, 2000 - journals.lww.com
The interaction of 4-1BB and its ligand plays an important role in the regulation of T-cell–
mediated immune responses. In this study, the authors examined the effect of a humanized
anti–4-1BB monoclonal antibody (H4B4) on ovalbumin-induced immune responses in
baboons. Previously, a mouse monoclonal antibody, 4B4 against the human 4-1BB
molecule, was generated and characterized. Based on this antibody, a humanized version
of 4B4 monoclonal antibody was constructed and the resultant antibody, H4B4, showed full …
mediated immune responses. In this study, the authors examined the effect of a humanized
anti–4-1BB monoclonal antibody (H4B4) on ovalbumin-induced immune responses in
baboons. Previously, a mouse monoclonal antibody, 4B4 against the human 4-1BB
molecule, was generated and characterized. Based on this antibody, a humanized version
of 4B4 monoclonal antibody was constructed and the resultant antibody, H4B4, showed full …
