[HTML][HTML] Calcium-activated potassium channels sustain calcium signaling in T lymphocytes: selective blockers and manipulated channel expression levels
CM Fanger, H Rauer, AL Neben, MJ Miller… - Journal of Biological …, 2001 - ASBMB
To maintain Ca 2+ entry during T lymphocyte activation, a balancing efflux of cations is
necessary. Using three approaches, we demonstrate that this cation efflux is mediated by Ca
2+-activated K+(K Ca) channels, hSKCa2 in the human leukemic T cell line Jurkat and
hIKCa1 in mitogen-activated human T cells. First, several recently developed, selective and
potent pharmacological inhibitors of K Ca channels but not KV channels reduce Ca 2+ entry
in Jurkat and in mitogen-activated human T cells. Second, dominant-negative suppression …
necessary. Using three approaches, we demonstrate that this cation efflux is mediated by Ca
2+-activated K+(K Ca) channels, hSKCa2 in the human leukemic T cell line Jurkat and
hIKCa1 in mitogen-activated human T cells. First, several recently developed, selective and
potent pharmacological inhibitors of K Ca channels but not KV channels reduce Ca 2+ entry
in Jurkat and in mitogen-activated human T cells. Second, dominant-negative suppression …
