Enhanced intestinal glucose and alanine transport in cystic fibrosis.
P Baxter, J Goldhill, J Hardcastle, PT Hardcastle… - Gut, 1990 - gut.bmj.com
P Baxter, J Goldhill, J Hardcastle, PT Hardcastle, CJ Taylor
Gut, 1990•gut.bmj.comThe rise in short-circuit current associated with the active transport of glucose and alanine
was measured in intestinal biopsy samples from children with cystic fibrosis. The glucose-
induced increase in the short-circuit current was greater in the cystic fibrosis tissues than in
control samples over the whole range of concentrations tested (2.5-35 mM), a reflection of
an increased maximum rate of transport. Similar results were obtained with alanine. These
findings suggest that active Na (+)-linked nutrient transport is enhanced in cystic fibrosis.
was measured in intestinal biopsy samples from children with cystic fibrosis. The glucose-
induced increase in the short-circuit current was greater in the cystic fibrosis tissues than in
control samples over the whole range of concentrations tested (2.5-35 mM), a reflection of
an increased maximum rate of transport. Similar results were obtained with alanine. These
findings suggest that active Na (+)-linked nutrient transport is enhanced in cystic fibrosis.
The rise in short-circuit current associated with the active transport of glucose and alanine was measured in intestinal biopsy samples from children with cystic fibrosis. The glucose-induced increase in the short-circuit current was greater in the cystic fibrosis tissues than in control samples over the whole range of concentrations tested (2.5-35 mM), a reflection of an increased maximum rate of transport. Similar results were obtained with alanine. These findings suggest that active Na(+)-linked nutrient transport is enhanced in cystic fibrosis.
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