[PDF][PDF] Immunoglobulin genes: generating diversity with AID and UNG
U Storb, J Stavnezer - Current biology, 2002 - cell.com
U Storb, J Stavnezer
Current biology, 2002•cell.comSomatic hypermutation and switch recombination of immunoglobulin genes require the
activity of the activation-induced deaminase, AID. Recent studies of mice deficient for the
uracil-DNA glycosylase UNG, which removes U from DNA, suggest that AID catalyses the
deamination of dC to dU during antibody diversification.
activity of the activation-induced deaminase, AID. Recent studies of mice deficient for the
uracil-DNA glycosylase UNG, which removes U from DNA, suggest that AID catalyses the
deamination of dC to dU during antibody diversification.
Abstract
Somatic hypermutation and switch recombination of immunoglobulin genes require the activity of the activation-induced deaminase, AID. Recent studies of mice deficient for the uracil-DNA glycosylase UNG, which removes U from DNA, suggest that AID catalyses the deamination of dC to dU during antibody diversification.
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