The immunopathological basis of acetylcholine receptor deficiency in myasthenia gravis
AG Engel - Progress in brain research, 1979 - Elsevier
Publisher Summary The synaptic dysfunction in myasthenia gravis (MG) is caused by a
deficiency of the nicotonic postsynaptic acetylcholine receptor (AChR) protein. The AChR
deficiency in acquired MG is caused by an autoimmune attack on the postsynaptic
membrane. Immunoglobulin G (IgG) can be localized at the MG end-plate with peroxidase-
labelled staphylococcal protein A, and the third component of complement (C3) can be
demonstrated with peroxidase-labelled anti-human C3 under experimental conditions …
deficiency of the nicotonic postsynaptic acetylcholine receptor (AChR) protein. The AChR
deficiency in acquired MG is caused by an autoimmune attack on the postsynaptic
membrane. Immunoglobulin G (IgG) can be localized at the MG end-plate with peroxidase-
labelled staphylococcal protein A, and the third component of complement (C3) can be
demonstrated with peroxidase-labelled anti-human C3 under experimental conditions …
