Delta-9-tetrahydrocannabinol: localization in body fat
DS Kreuz, J Axelrod - Science, 1973 - science.org
DS Kreuz, J Axelrod
Science, 1973•science.org[14C] Δ9-Tetrahydrocannabinol (Δ9THC) was injected subcutaneously in rats every day for
1 to 26 days. Concentrations of Δ9THC and its metabolites, 11-hydroxytetrahydrocannabinol
and 8, 11-dihydroxytetrahydrocannabinol, were determined in various tissues. After a single
injection, the concentration of Δ9THC in fat was ten times greater than in any other tissue
examined, and persisted in this tissue for 2 weeks. With repeated injection, Δ9THC and its
metabolites accumulated in fat and brain.
1 to 26 days. Concentrations of Δ9THC and its metabolites, 11-hydroxytetrahydrocannabinol
and 8, 11-dihydroxytetrahydrocannabinol, were determined in various tissues. After a single
injection, the concentration of Δ9THC in fat was ten times greater than in any other tissue
examined, and persisted in this tissue for 2 weeks. With repeated injection, Δ9THC and its
metabolites accumulated in fat and brain.
[14C]Δ9-Tetrahydrocannabinol (Δ9THC) was injected subcutaneously in rats every day for 1 to 26 days. Concentrations of Δ9THC and its metabolites, 11-hydroxytetrahydrocannabinol and 8,11-dihydroxytetrahydrocannabinol, were determined in various tissues. After a single injection, the concentration of Δ9THC in fat was ten times greater than in any other tissue examined, and persisted in this tissue for 2 weeks. With repeated injection, Δ9THC and its metabolites accumulated in fat and brain.
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