Inhibition of human allergic T-cell responses by IL-10–treated dendritic cells: Differences from hydrocortisone-treated dendritic cells
I Bellinghausen, U Brand, K Steinbrink, AH Enk… - Journal of allergy and …, 2001 - Elsevier
Background: Dendritic cells (DCs) are able to induce human allergic TH1 responses as well
as TH2 responses. Objective: In this study, we examined the effect of antiinflammatory
agents such as IL-10 and hydrocortisone (HC) on the accessory function of DCs and the
resulting T-cell response, especially that of TH2 cells. Methods: Naive and memory CD4+ T
cells from atopic donors were stimulated with autologous allergen-pulsed DCs generated
from CD14+ monocytes by culture with GM-CSF/IL-4 and fully matured with IL-1β, TNF-α …
as TH2 responses. Objective: In this study, we examined the effect of antiinflammatory
agents such as IL-10 and hydrocortisone (HC) on the accessory function of DCs and the
resulting T-cell response, especially that of TH2 cells. Methods: Naive and memory CD4+ T
cells from atopic donors were stimulated with autologous allergen-pulsed DCs generated
from CD14+ monocytes by culture with GM-CSF/IL-4 and fully matured with IL-1β, TNF-α …
