Production of prostaglandins and leukotrienes by pathogenic fungi
MC Noverr, GB Toews, GB Huffnagle - Infection and immunity, 2002 - Am Soc Microbiol
MC Noverr, GB Toews, GB Huffnagle
Infection and immunity, 2002•Am Soc MicrobiolThese studies demonstrate that pathogenic fungi (dermatophytic, subcutaneous, and
systemic) have the ability to produce eicosanoids both from simple metabolites and from
arachidonic acid. Host-derived eicosanoids have been previously demonstrated to enhance
fungal colonization and atopic disease development. Thus, fungus-derived eicosanoids
represent a potential class of novel virulence factors.
systemic) have the ability to produce eicosanoids both from simple metabolites and from
arachidonic acid. Host-derived eicosanoids have been previously demonstrated to enhance
fungal colonization and atopic disease development. Thus, fungus-derived eicosanoids
represent a potential class of novel virulence factors.
Abstract
These studies demonstrate that pathogenic fungi (dermatophytic, subcutaneous, and systemic) have the ability to produce eicosanoids both from simple metabolites and from arachidonic acid. Host-derived eicosanoids have been previously demonstrated to enhance fungal colonization and atopic disease development. Thus, fungus-derived eicosanoids represent a potential class of novel virulence factors.
American Society for Microbiology