Despite the generally restrictive nature of the blood–brain barrier (BBB), circulating
lymphocytes can infiltrate into the central nervous system (CNS) during a variety of disease
states. Although the contributions of these lymphocytes to CNS-associated disease have
been identified in some viral models, the factors which govern this infiltration following
herpes simplex virus (HSV) infection remain to be elucidated. We have developed a murine
model of HSV encephalitis (HSE) to define the relationship among psychological stress, the …