[HTML][HTML] Bcl-2 family gene expression during severe hyperoxia induced lung injury
MA O'Reilly, RJ Staversky, HL Huyck, RH Watkins… - Laboratory …, 2000 - Elsevier
Exposure of the lung to severe hyperoxia induces terminal transferase dUTP end-labeling
(TUNEL) indicative of DNA damage or apoptosis and increases expression of the tumor
suppressor p53 and of members of the Bcl-2 gene family. Because cell survival and
apoptosis are regulated, in part, by the relative abundance of proteins of the Bcl-2 family, we
hypothesized that lung cells dying during exposure would show increased expression of pro-
apoptotic members, such as Bax, whereas surviving cells would have increased expression …
(TUNEL) indicative of DNA damage or apoptosis and increases expression of the tumor
suppressor p53 and of members of the Bcl-2 gene family. Because cell survival and
apoptosis are regulated, in part, by the relative abundance of proteins of the Bcl-2 family, we
hypothesized that lung cells dying during exposure would show increased expression of pro-
apoptotic members, such as Bax, whereas surviving cells would have increased expression …