Salicylates, including aspirin, have been shown to improve insulin sensitivity both in human
and animal models. Although it has been suggested that salicylates sensitize insulin action
by inhibiting IκB kinase β (IKKβ), the detailed mechanisms remain unclear. Protein kinase C
isoforms and tumor necrosis factor α (TNFα) signaling pathways are well described
mediators of insulin resistance; they are implicated in the activation of IKKβ and the
subsequent inhibition of proximal insulin signaling via insulin receptor substrate 1 (IRS1) …