The murine fatty acid transport protein (FATP) was identified on the basis of its ability to
facilitate uptake of long chain fatty acids (LCFAs) when expressed in mammalian cells. To
delineate FATP domains important for transport function, we cloned the human heart FATP
ortholog. Comparison of the human, murine, and yeast amino acid sequences identified a
highly conserved motif, IYTSGTTGXPK, also found in a number of proteins that form
adenylated intermediates. We demonstrate that depletion of intracellular ATP dramatically …