[HTML][HTML] FATP1 channels exogenous FA into 1, 2, 3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells
GM Hatch, AJ Smith, FY Xu, AM Hall… - Journal of lipid research, 2002 - ASBMB
Biosynthesis of lipids was investigated in growing 293 cells stably expressing fatty acid (FA)
transport protein 1 (FATP1), a bifunctional polypeptide with FA transport as well as fatty acyl-
CoA synthetase activity. In short-term (30 s) incubations, FA uptake was increased in FATP1
expressing cells (C8 cells) compared with the vector (as determined by BODIPY 3823
staining and radioactive FA uptake). In long-term (4 h) incubations, incorporation of [14 C]
acetate,[3H] oleic acid, or [14 C] lignoceric acid into 1, 2, 3-triacyl-sn-glycerol (TG) was …
transport protein 1 (FATP1), a bifunctional polypeptide with FA transport as well as fatty acyl-
CoA synthetase activity. In short-term (30 s) incubations, FA uptake was increased in FATP1
expressing cells (C8 cells) compared with the vector (as determined by BODIPY 3823
staining and radioactive FA uptake). In long-term (4 h) incubations, incorporation of [14 C]
acetate,[3H] oleic acid, or [14 C] lignoceric acid into 1, 2, 3-triacyl-sn-glycerol (TG) was …