[HTML][HTML] Vectorial acylation in Saccharomyces cerevisiae: Fat1p and fatty acyl-CoA synthetase are interacting components of a fatty acid import complex
Z Zou, F Tong, NJ Færgeman, C Børsting… - Journal of Biological …, 2003 - ASBMB
In Saccharomyces cerevisiae Fat1p and fatty acyl-CoA synthetase (FACS) are hypothesized
to couple import and activation of exogenous fatty acids by a process called vectorial
acylation. Molecular genetic and biochemical studies were used to define further the
functional and physical interactions between these proteins. Multicopy extragenic
suppressors were selected in strains carrying deletions inFAA1 and FAA4 or FAA1
andFAT1. Each strain is unable to grow under synthetic lethal conditions when exogenous …
to couple import and activation of exogenous fatty acids by a process called vectorial
acylation. Molecular genetic and biochemical studies were used to define further the
functional and physical interactions between these proteins. Multicopy extragenic
suppressors were selected in strains carrying deletions inFAA1 and FAA4 or FAA1
andFAT1. Each strain is unable to grow under synthetic lethal conditions when exogenous …