Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis: a new syndrome
FC Bartter, P Pronove, JR Gill Jr… - The American journal of …, 1962 - Elsevier
A new syndrome, characterized by hypertrophy and hyperplasia of the juxtaglomerular
apparatus of the kidneys, aldosteronism resulting from adrenal cortical hyperplasia, and
persistently normal blood pressure is described in two patients. Overproduction of
aldosterone could not be prevented by sodium loading or by administration of albumin
intravenously; it was associated with hypokalemic alkalosis and Pitressin-resistant
impairment of urinary concentrating ability. In both subjects, increased amounts of circulating …
apparatus of the kidneys, aldosteronism resulting from adrenal cortical hyperplasia, and
persistently normal blood pressure is described in two patients. Overproduction of
aldosterone could not be prevented by sodium loading or by administration of albumin
intravenously; it was associated with hypokalemic alkalosis and Pitressin-resistant
impairment of urinary concentrating ability. In both subjects, increased amounts of circulating …