A meta-analysis of genome-wide linkage scans for hypertension: the National Heart, Lung and Blood Institute Family Blood Pressure Program
MA Province, SLR Kardia, K Ranade… - American journal of …, 2003 - academic.oup.com
American journal of hypertension, 2003•academic.oup.com
Abstract Background: Four multicenter Networks (GenNet, GENOA, HyperGEN, SAPPHIRe)
form the National Heart, Lung and Blood Institute Family Blood Pressure Program (FBPP), to
search for hypertension/blood pressure (BP) genes. The networks used different family
designs and targeted multiple ethnic groups, using standardized protocols and definitions.
Linkage genome scans were done on samples within each network (N= 6245 relatives).
Methods: The evidence was synthesized using meta-analysis. Results: Combining ethnic …
form the National Heart, Lung and Blood Institute Family Blood Pressure Program (FBPP), to
search for hypertension/blood pressure (BP) genes. The networks used different family
designs and targeted multiple ethnic groups, using standardized protocols and definitions.
Linkage genome scans were done on samples within each network (N= 6245 relatives).
Methods: The evidence was synthesized using meta-analysis. Results: Combining ethnic …
Background
Four multicenter Networks (GenNet, GENOA, HyperGEN, SAPPHIRe) form the National Heart, Lung and Blood Institute Family Blood Pressure Program (FBPP), to search for hypertension/blood pressure (BP) genes. The networks used different family designs and targeted multiple ethnic groups, using standardized protocols and definitions. Linkage genome scans were done on samples within each network (N = 6245 relatives).
Methods
The evidence was synthesized using meta-analysis.
Results
Combining ethnic groups, no region reached LOD >2, but several small peaks were identified, including chromosome 2p where two other recent reports find hypertension linkage.
Conclusions
No regions show uniformly large effects on BP/hypertension in all populations. Am J Hypertens 2003;16:144–147 @ 2003 American Journal of Hypertension, Ltd.
Oxford University Press