[HTML][HTML] Homeostasis in mice with genetically decreased angiotensinogen is primarily by an increased number of renin-producing cells
HS Kim, N Maeda, GT Oh, LG Fernandez… - Journal of Biological …, 1999 - ASBMB
Here we investigate the biochemical, molecular, and cellular changes directed toward blood
pressure homeostasis that occur in the endocrine branch of the renin-angiotensin system of
mice having one angiotensinogen gene inactivated. No compensatory up-regulation of the
remaining normal allele occurs in the liver, the main tissue of angiotensinogen synthesis. No
significant changes occur in expression of the genes coding for the angiotensin converting
enzyme or the major pressor-mediating receptor for angiotensin, but plasma renin …
pressure homeostasis that occur in the endocrine branch of the renin-angiotensin system of
mice having one angiotensinogen gene inactivated. No compensatory up-regulation of the
remaining normal allele occurs in the liver, the main tissue of angiotensinogen synthesis. No
significant changes occur in expression of the genes coding for the angiotensin converting
enzyme or the major pressor-mediating receptor for angiotensin, but plasma renin …