Hapten-induced chronic colitis in the rat: alternatives to trinitrobenzene sulfonic acid
JL Wallace, T Le, L Carter, CB Appleyard… - … of pharmacological and …, 1995 - Elsevier
Hapten-induced colitis is a widely used model for the study of the intestinal inflammation and
for the testing of novel therapies. However, the hapten utilized in this model, trinitrobenzene
sulfonic acid, is difficult to obtain in some countries. We therefore compared this hapten to
two structurally related haptens to determine if they could be substituted for trinitrobenzene
sulfonic acid in terms of inducing chronic colitis in the rat. Rats received one of the three
haptens intracolonically, and the severity of colonic inflammation was assessed 3 and 14 …
for the testing of novel therapies. However, the hapten utilized in this model, trinitrobenzene
sulfonic acid, is difficult to obtain in some countries. We therefore compared this hapten to
two structurally related haptens to determine if they could be substituted for trinitrobenzene
sulfonic acid in terms of inducing chronic colitis in the rat. Rats received one of the three
haptens intracolonically, and the severity of colonic inflammation was assessed 3 and 14 …