[HTML][HTML] Identification of a novel NF-κB-binding site with regulation of the murine α2 (I) collagen promoter
G Novitskiy, JJ Potter, L Rennie-Tankersley… - Journal of Biological …, 2004 - ASBMB
Hepatic fibrosis is due to the increased synthesis and deposition of type I collagen.
Acetaldehyde activates type I collagen promoters. Nuclear factor κB (NF-κB) was previously
shown to inhibit expression of murine α 1 (I) and human α 2 (I) collagen promoters. The
present study identifies binding of NF-κB, present in nuclear extracts of stellate cells, to a
region between-553 and-537 of the murine α 2 (I) collagen promoter. The NF-κB (p65)
expression vector inhibited promoter activity. Mutation of the promoter at the NF-κB-binding …
Acetaldehyde activates type I collagen promoters. Nuclear factor κB (NF-κB) was previously
shown to inhibit expression of murine α 1 (I) and human α 2 (I) collagen promoters. The
present study identifies binding of NF-κB, present in nuclear extracts of stellate cells, to a
region between-553 and-537 of the murine α 2 (I) collagen promoter. The NF-κB (p65)
expression vector inhibited promoter activity. Mutation of the promoter at the NF-κB-binding …