AMP-activated protein kinase (AMPK) control of fatty acid and glucose metabolism in the ischemic heart
N Sambandam, GD Lopaschuk - Progress in lipid research, 2003 - Elsevier
Myocardial ischemia is the leading cause of all cardiovascular deaths in North America.
Myocardial ischemia is accompanied by profound changes in metabolism including
alterations in glucose and fatty acid metabolism, increased uncoupling of glucose oxidation
from glycolysis and accumulation of protons within the myocardium. These changes can
contribute to a poor functional recovery of the heart. One key player in the ischemia-induced
alteration in fatty acid and glucose metabolism is 5′ AMP-activated protein kinase (AMPK) …
Myocardial ischemia is accompanied by profound changes in metabolism including
alterations in glucose and fatty acid metabolism, increased uncoupling of glucose oxidation
from glycolysis and accumulation of protons within the myocardium. These changes can
contribute to a poor functional recovery of the heart. One key player in the ischemia-induced
alteration in fatty acid and glucose metabolism is 5′ AMP-activated protein kinase (AMPK) …
