Emerging therapies: controlling glucose homeostasis, immunotherapy, islet transplantation, gene therapy, and islet cell neogenesis and regeneration
JA Ruggles, D Kelemen, A Baron - … and Metabolism Clinics, 2004 - endo.theclinics.com
Type 1 diabetes (T1D) is a chronic, incurable disease that results from the selective immune-
mediated autoreactive T-cell destruction of b cells in the islet of Langerhans [1–3]. It is
characterized by absolute insulin deficiency. Since the discovery of insulin more than 80
years ago and the advent of glucose monitoring, considerable advances in insulin therapy
have occurred [4, 5], yet many patients who have T1D still fail to achieve glycemic targets. In
the Diabetes Control and Complications Trial, fewer than 5% of intensively treated patients …
mediated autoreactive T-cell destruction of b cells in the islet of Langerhans [1–3]. It is
characterized by absolute insulin deficiency. Since the discovery of insulin more than 80
years ago and the advent of glucose monitoring, considerable advances in insulin therapy
have occurred [4, 5], yet many patients who have T1D still fail to achieve glycemic targets. In
the Diabetes Control and Complications Trial, fewer than 5% of intensively treated patients …