Effects of retinoids on the TGF-β system and extracellular matrix in experimental glomerulonephritis
C Morath, C Dechow, I Lehrke, V Haxsen… - Journal of the …, 2001 - journals.lww.com
Transforming growth factor—β1 (TGF-β1) overexpression plays a key role in the glomerular
accumulation of extracellular matrix proteins in renal disease. Retinoids have previously
been shown to significantly limit glomerular damage in rat experimental glomerulonephritis.
Therefore, the effects of all-trans retinoic acid and isotretinoin on the components of the TGF-
β system and extracellular matrix proteins in anti-Thy1. 1-nephritis (Thy-GN) were
investigated. Vehicle-injected control rats were compared with rats treated with daily …
accumulation of extracellular matrix proteins in renal disease. Retinoids have previously
been shown to significantly limit glomerular damage in rat experimental glomerulonephritis.
Therefore, the effects of all-trans retinoic acid and isotretinoin on the components of the TGF-
β system and extracellular matrix proteins in anti-Thy1. 1-nephritis (Thy-GN) were
investigated. Vehicle-injected control rats were compared with rats treated with daily …
