The structural biology of type I viral membrane fusion
PM Colman, MC Lawrence - Nature Reviews Molecular Cell Biology, 2003 - nature.com
Nature Reviews Molecular Cell Biology, 2003•nature.com
The fusion of viral membranes with target-cell membranes is an essential step in the entry of
enveloped viruses into cells, and recent X-ray structures of paramyxoviral envelope proteins
have provided new insights into protein-mediated plasma-membrane fusion. Here, we
review our understanding of the structural transitions that are involved in this fusion pathway,
compare it to our understanding of influenza virus membrane fusion, and discuss the
implications for retroviral membrane fusion.
enveloped viruses into cells, and recent X-ray structures of paramyxoviral envelope proteins
have provided new insights into protein-mediated plasma-membrane fusion. Here, we
review our understanding of the structural transitions that are involved in this fusion pathway,
compare it to our understanding of influenza virus membrane fusion, and discuss the
implications for retroviral membrane fusion.
Abstract
The fusion of viral membranes with target-cell membranes is an essential step in the entry of enveloped viruses into cells, and recent X-ray structures of paramyxoviral envelope proteins have provided new insights into protein-mediated plasma-membrane fusion. Here, we review our understanding of the structural transitions that are involved in this fusion pathway, compare it to our understanding of influenza virus membrane fusion, and discuss the implications for retroviral membrane fusion.
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