Loss of expression of transforming growth factor-beta receptor as a prognostic factor in patients with renal cell carcinoma
A Miyajima, T Asano, K Seta, T Asano, N Kakoi… - Urology, 2003 - Elsevier
OBJECTIVES: To determine the clinical implication of the loss of transforming growth factor-
beta (TGF-β) receptor (TβR) expression for the pathologic features in renal cell carcinoma
(RCC) and the prognosis of 62 patients (Stage I, 4; Stage II, 28; Stage III, 11; and Stage IV,
19) who underwent radical nephrectomy for RCC. Loss of expression in TβR could result in
escape from the growth inhibitory effect of TGF-β in TGF-β-secreting cancer. METHODS:
TβR and apoptosis in the tumor were detected by immunohistochemistry using samples from …
beta (TGF-β) receptor (TβR) expression for the pathologic features in renal cell carcinoma
(RCC) and the prognosis of 62 patients (Stage I, 4; Stage II, 28; Stage III, 11; and Stage IV,
19) who underwent radical nephrectomy for RCC. Loss of expression in TβR could result in
escape from the growth inhibitory effect of TGF-β in TGF-β-secreting cancer. METHODS:
TβR and apoptosis in the tumor were detected by immunohistochemistry using samples from …
