Role of MAP kinase in tumor progression and invasion
KB Reddy, SM Nabha, N Atanaskova - Cancer and Metastasis Reviews, 2003 - Springer
KB Reddy, SM Nabha, N Atanaskova
Cancer and Metastasis Reviews, 2003•SpringerActivation of the mitogen-activated protein kinase/extracellular signal-regulated kinase
(MAPK/ERK) pathway is a frequent event in tumorigenesis. MAPKs have been implicated in
cell migration, proteinase-induction, regulation of apoptosis, and angiogenesis, events that
are essential for successful completion of metastasis. In this review, we discuss the potential
role that MAPKs play in metastasis by regulating cell migration, proteinase-induction and
apoptosis.
(MAPK/ERK) pathway is a frequent event in tumorigenesis. MAPKs have been implicated in
cell migration, proteinase-induction, regulation of apoptosis, and angiogenesis, events that
are essential for successful completion of metastasis. In this review, we discuss the potential
role that MAPKs play in metastasis by regulating cell migration, proteinase-induction and
apoptosis.
Abstract
Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway is a frequent event in tumorigenesis. MAPKs have been implicated in cell migration, proteinase-induction, regulation of apoptosis, and angiogenesis, events that are essential for successful completion of metastasis. In this review, we discuss the potential role that MAPKs play in metastasis by regulating cell migration, proteinase-induction and apoptosis.
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