[HTML][HTML] Ultraviolet A-induced modulation of Bcl-XL by p38 MAPK in human keratinocytes: post-transcriptional regulation through the 3′-untranslated region
MA Bachelor, GT Bowden - Journal of Biological Chemistry, 2004 - ASBMB
We examined the effect of inhibiting p38 MAPK on UVA-irradiated HaCaT cells, a
spontaneously immortalized human keratinocyte cell line. Recent work from our laboratory
has shown that UVA (250 kJ/m 2) induces a rapid phosphorylation of p38 MAPK in the
HaCaT cell line. Inhibition of p38 MAPK activity through the use of a specific inhibitor,
SB202190, in combination with UVA treatment induced a rapid cleavage of caspase-9,
caspase-8, and caspase-3, whereas UVA irradiation alone had no effect. Similarly, cleavage …
spontaneously immortalized human keratinocyte cell line. Recent work from our laboratory
has shown that UVA (250 kJ/m 2) induces a rapid phosphorylation of p38 MAPK in the
HaCaT cell line. Inhibition of p38 MAPK activity through the use of a specific inhibitor,
SB202190, in combination with UVA treatment induced a rapid cleavage of caspase-9,
caspase-8, and caspase-3, whereas UVA irradiation alone had no effect. Similarly, cleavage …
