Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma
H Hahn, L Wojnowski, K Specht, R Kappler… - Journal of Biological …, 2000 - ASBMB
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children (Dagher, R.,
and Helman, L.(1999) Oncologist 4, 34–44), whereas medulloblastoma, a highly malignant
tumor of the cerebellum, accounts for 20% of childhood brain tumors (Goodrich, LV, and
Scott, MP (1998) Neuron 21, 1243–1257). Both tumors are associated with a deficiency in
the tumor suppressorPatched (PTCH) in Gorlin syndrome (Gorlin, RJ (1987) Medicine
(Baltimore) 66, 98–113), and they are present in the corresponding murine models. RMS in …
and Helman, L.(1999) Oncologist 4, 34–44), whereas medulloblastoma, a highly malignant
tumor of the cerebellum, accounts for 20% of childhood brain tumors (Goodrich, LV, and
Scott, MP (1998) Neuron 21, 1243–1257). Both tumors are associated with a deficiency in
the tumor suppressorPatched (PTCH) in Gorlin syndrome (Gorlin, RJ (1987) Medicine
(Baltimore) 66, 98–113), and they are present in the corresponding murine models. RMS in …
