A novel NF-κB-inducing kinase-MAPK signaling pathway up-regulates NF-κB activity in melanoma cells
P Dhawan, A Richmond - Journal of Biological Chemistry, 2002 - ASBMB
Constitutive activation of NF-κB is an emerging hallmark of various types of tumors including
breast, colon, pancreatic, ovarian, and melanoma. In melanoma cells, the basal expression
of the CXC chemokine, CXCL1, is constitutively up-regulated. This up-regulation can be
attributed in part to constitutive activation of NF-κB. Previous studies have shown an
elevated basal IκB kinase (IKK) activity in Hs294T melanoma cells, which leads to an
increased rate of IκB phosphorylation and degradation. This increase in IκB-α …
breast, colon, pancreatic, ovarian, and melanoma. In melanoma cells, the basal expression
of the CXC chemokine, CXCL1, is constitutively up-regulated. This up-regulation can be
attributed in part to constitutive activation of NF-κB. Previous studies have shown an
elevated basal IκB kinase (IKK) activity in Hs294T melanoma cells, which leads to an
increased rate of IκB phosphorylation and degradation. This increase in IκB-α …
