Activation of p38 mitogen-activated protein kinase by signaling through G protein-coupled receptors: involvement of Gβγ and Gαq/11 subunits
J Yamauchi, M Nagao, Y Kaziro, H Itoh - Journal of Biological Chemistry, 1997 - ASBMB
Various extracellular stimuli activate three classes of mitogen-activated protein kinases
(MAPKs): extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38 MAPK. In
mammalian cells, p38 MAPK is activated by endotoxins, inflammatory cytokines, and
environmental stresses. We show here that p38 MAPK is also activated upon stimulation of
G protein-coupled receptors (G q/G 11-coupled m1 and G i-coupled m2 muscarinic
acetylcholine and G s-coupled β-adrenergic receptors) in human embryonal kidney 293 …
(MAPKs): extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38 MAPK. In
mammalian cells, p38 MAPK is activated by endotoxins, inflammatory cytokines, and
environmental stresses. We show here that p38 MAPK is also activated upon stimulation of
G protein-coupled receptors (G q/G 11-coupled m1 and G i-coupled m2 muscarinic
acetylcholine and G s-coupled β-adrenergic receptors) in human embryonal kidney 293 …
