Interleukin 2 leads to dose-dependent expression of the alpha chain of the IL-2 receptor on CD25-negative T lymphocytes in the absence of exogenous antigenic …
I Sereti, J Gea-Banacloche, MY Kan, CW Hallahan… - Clinical …, 2000 - Elsevier
Expression of the α chain of the interleukin 2 receptor on T lymphocytes is restricted,
increasing in the setting of activation, particularly after antigenic stimulation via the TCR. The
effects of IL-2 in vitro on the expression of CD25 and proliferation as well as the cytokine
induction in CD25-depleted T cells were studied. CD25-depleted and PBMC of healthy
donors were cultured for 7 days with 0, 10, or 100 IU/ml of IL-2. Phenotypic analysis and
measurement of cytokines in the culture supernatants were performed. IL-2 led to a dose …
increasing in the setting of activation, particularly after antigenic stimulation via the TCR. The
effects of IL-2 in vitro on the expression of CD25 and proliferation as well as the cytokine
induction in CD25-depleted T cells were studied. CD25-depleted and PBMC of healthy
donors were cultured for 7 days with 0, 10, or 100 IU/ml of IL-2. Phenotypic analysis and
measurement of cytokines in the culture supernatants were performed. IL-2 led to a dose …
